Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE)
نویسندگان
چکیده
Here we show that designed transcription activator-like effectors (TALEs) that bind to defined areas of the interferon beta promoter are capable to induce IFN-beta expression and signaling in human cells. Importantly, TALE-mediated IFN-beta signaling occurs independently of pathogen pattern recognition but effectively prohibits viral RNA replication as demonstrated with a hepatitis C virus replicon. TALEs were thus indicated to be valuable tools in various applications addressing, for example, virus-host interactions.
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2014